Engineering the mitral valve:

bioinspired control of structure and function for enhanced in vivo performance

Patents

US20220249226A1
PCT/US2018/019358
Applicants

The underlying patent portfolio is exclusively licensed for commercial development to Neoolife, Inc., Pittsburgh, USA (https://neoolife.com)

Status
Published

A stentless biopolymer heart valve replacement capable of living tissue regeneration

Abstract

A template for a valve construct for replacement of at least one of a mitral valve and a tricuspid valve includes at least an anterior leaflet portion and at least a posterior leaflet portion, each leaflet portion having a proximal edge, a distal edge, and side edges extending between the proximal edge and the distal edge. The template further includes a plurality of substantially straight elongated chordae portions each having a proximal end connected to the distal edge of one of the at least two leaflet portions and a distal end extending therefrom and one or more papillary muscle head portions formed at a commissure between distal ends of at least two of the plurality of chordae portions. A total width of the leaflet portions of the template is substantially equal to a circumference of a native annulus of a heart valve.

Inventors

Vinay Badhwar

Antonio D’Amore

Yasumoto Matsumura

William R. Wagner

US 11,680,341 B2
PCT/US2018/022863
Applicants

The underlying patent portfolio is exclusively licensed for commercial development to Neoolife, Inc., Pittsburgh, USA (https://neoolife.com)

Status
Published

Mandrel-less Electrospinning Processing Method and System, and Uses Therefor

Abstract

According to one aspect of the invention, a mandrel-less electrodeposition system for use in preparing a filament is provided. The system comprises: two or more static or rotating target electrodes having opposing, spaced-apart tips electrically-connected to an electrical power source, the opposing tips of the electrodes defining a deposition target axis; a nozzle electrically-connected to a second electrical power source and spaced apart from the target electrodes and the deposition target axis; and a reservoir configured to deliver a polymer composition through the nozzle and to the deposition target axis.

Inventors

William R. Wagner

Antonio D’Amore

US 2024/0016983 A1
PCT/US21/054767
Applicants

The underlying patent portfolio is exclusively licensed for commercial development to Neoolife, Inc., Pittsburgh, USA (https://neoolife.com)

Status
Published

Hybrid Micro Molding-Fiber Deposition Substrate Processing for Cell Biology Manipulation and Local Anisotropy

Abstract

Methods, systems and devices are provided herein for preparing fiber matrices with differing degrees of anisotropy within a single matrix and controllable physical parameters, suhs as porosity.

Inventors

William R. Wagner

Pietro Terranova

Arianna Adamo

Antonio D’Amore

US-2021-129711-B1
PCT/US2016/019837
Applicants

The underlying patent portfolio is exclusively licensed for commercial development to Neoolife, Inc., Pittsburgh, USA (https://neoolife.com)

Status
Published

Double Component Mandrel for Electrospun Stentless, Multi-leaflet Valve Fabrication

Abstract

A method of making a valve structure includes a step of rotating a mandrel and an electrodeposition target attached to the mandrel about a rotational axis of the mandrel.

Inventors

Antonio D’Amore

Vinay Badhwar

Young Jae Chun

William R. Wagner

Engineering the mitral valve:

bioinspired control of structure and function for enhanced in vivo performance